THE SYNTHESIS OF A NOVEL BIBENZOPYRAN RELIED ON ELECTROOXYDATION OF MALLOAPELTA B BY CYCLIC VOLTAMMETRY

Authors

Binh Phan Thi
Ninh Bui Hai
Minh Chau Van
Nam Nguyen Hoai
Huong Le Mai
Kiem Phan Van

Abstract

A novel bibenzopyran named bimalloapelta (1) was synthesized relying on electrooxydation of malloapelta B by cyclic voltammetry in acetonitril adding LiClO4 0.1 M as supporting electrolyte. Its structure determination based on extensive NMR studies and ESI mass spectral measurements. The new compound showed significant cytotoxicity againsts two cancer cell lines as human hepatocellular carcinoma (Hep-2; IC50: 0.46 µg/m) and rhabdosarcoma (RD; IC50: 0.33 µg/m). These results were the same that of malloapelta B (Hep-2, IC50: 0.49 µg/ml and KB, IC50: 0.54 µg/ml).

Publication Date

11-16-2017

Recommended Citation

Thi, Binh Phan; Hai, Ninh Bui; Van, Minh Chau; Hoai, Nam Nguyen; Mai, Huong Le; and Van, Kiem Phan (2017) "THE SYNTHESIS OF A NOVEL BIBENZOPYRAN RELIED ON ELECTROOXYDATION OF MALLOAPELTA B BY CYCLIC VOLTAMMETRY," ASEAN Journal on Science and Technology for Development: Vol. 24: No. 4, Article 4.
DOI: https://doi.org/10.29037/ajstd.210
Available at: https://ajstd.ubd.edu.bn/journal/vol24/iss4/4