Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia

Authors

Poedjomartono Bagaswoto
Afkari Hanif
Meiyanto Edy
Bangun Alan
Sardjono Yohanes

Abstract

Boron neutron capture therapy (BNCT) is a form of cancer therapy based on the interaction of low-energy thermal neutrons and boron-10 (10-B) to produce alpha radiation from He-4 and Li-7 with a high linear energy transfer. A beam of neutrons irradiates a boron drug injected into the tumor, resulting in the boron-injected cancer cells receiving a lethal dose of radiation with the surrounding, healthy cells being minimally affected. Two boron drugs have been used clinically in BNCT, boron sodium captate (BSH) and borophenylalanine (BPA), while a third, pentagamaboronon-0 (PGB-0), is currently under development in the Faculty of Pharmacy of Universitas Gadjah Mada, Indonesia. In Indonesia, there has been a growing interest in the study and use of BNCT to treat cancer, as this method is expected to be safer and more effective than traditional cancer treatment methods.

Publication Date

7-17-2020

Recommended Citation

Bagaswoto, Poedjomartono; Hanif, Afkari; Edy, Meiyanto; Alan, Bangun; and Yohanes, Sardjono (2020) "Boron Neutron Capture Therapy for Cancer: Future Prospects in Indonesia," ASEAN Journal on Science and Technology for Development: Vol. 35: No. 3, Article 5.
DOI: https://doi.org/10.29037/ajstd.510
Available at: https://ajstd.ubd.edu.bn/journal/vol35/iss3/5