Potential of Green Synthesis of Silver and Gold Nanoparticles for the Management of Metabolic Associated Steatotic Liver Disease: A Mini Review

Authors

Atiqah Suhaili, Environmental and Life Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE1410, Brunei Darussalam
Ya Chee Lim, PAPRSB Institute of Health Sciences, Jalan Tungku Link, Gadong, Universiti Brunei Darussalam.
Mei Ann Lim, PAPRSB Institute of Health Sciences, Jalan Tungku Link, Gadong, Universiti Brunei Darussalam.
Lee Hoon Lim, cChemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam.Follow
Mohammad Mansoob Khan, Chemical Sciences, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong, BE 1410, Brunei Darussalam
Monowarul Mobin Siddique, Department of Nutrition and Integrative Physiology, University of Utah, Salt Lake City, United States

Abstract

Metabolic-associated steatotic liver disease is a metabolic disorder with limited pharmacological treatment options and only one approved medication to date. MASLD can be asymptomatic in its earlier stage and hence, prevention of this disease progression is the most effective approach. Recently, green-synthesized nanoparticles, particularly silver (AgNPs) and gold nanoparticles (AuNPs), have gained interest due to their eco-friendly production, biocompatibility, and bioactive properties. This review highlights the biosynthesis of AgNPs and AuNPs using medicinal plant extracts and their reported biological effects relevant to MASLD management including anti-hyperlipidemic, anti-diabetic, antioxidant and anti-inflammatory activities. While findings are promising, further mechanistic studies and preclinical validation are required to facilitate their use as targeted therapies for MASLD.

Keywords

Green synthesis; Nanoparticles; Metabolic syndrome; Metabolic dysfunction-associated steatotic liver disease.

Publication Date

2025

Received Date

15/05/2025

Revised Date

27/05/2025

Accepted Date

05/06/2025

Recommended Citation

Suhaili, Atiqah; Lim, Ya Chee; Lim, Mei Ann; Lim, Lee Hoon; Khan, Mohammad Mansoob; and Siddique, Monowarul Mobin (2025) "Potential of Green Synthesis of Silver and Gold Nanoparticles for the Management of Metabolic Associated Steatotic Liver Disease: A Mini Review," ASEAN Journal on Science and Technology for Development: Vol. 43: No. 1, Article 7.
DOI: https://doi.org/10.61931/2224-9028.1633
Available at: https://ajstd.ubd.edu.bn/journal/vol43/iss1/7